A Natural Cattle Immune Response Against Horn Fly (Diptera: Muscidae) Salivary Antigens May Regulate Parasite Blood Intake

Posted by Ernesto on Tuesday, 3 June 2025
Autores: 
M Breijo 1 , L Pastro 2 , S Rocha 3 , X Ures 3 , P Alonzo 3 , M Santos 3 , C Bolatto 4 , C Fernández 5 , A Meikle 6
Revista (o libro): 
J Econ Entomol
Año: 
2016
Mes-dia: 
0800
issue, vol, paginas, etc: 
109(4):1951-6
doi: 
10.1093/jee/tow133
PMID: 
27329632
Abstract: 
The horn fly, Haematobia irritans (L.), is a blood-sucking ectoparasite that is responsible for sizeable economic losses in livestock. The salivary gland products facilitate blood intake. Taking advantage of the identification of novel H. irritans salivary antigens (Hematobin, HTB and Irritans 5, IT5), we investigated the parasite loads, H. irritans blood intake, and antibody response of naturally infected bovines during the fly season. Fly loads and fly hemoglobin content fluctuated during the trial. Each time horn fly loads exceeded 200 flies per cattle, a reduction in horn fly blood intake was observed three weeks later. All of the cattle elicited an antibody response against HTB and IT5 that declined once the fly season was over. Cattle anti-IT5 titers were positively correlated with parasite loads and negatively correlated with fly blood intake. These results suggest that the natural changes in the H. irritans blood intake observed in this study were associated with a natural host response against horn fly salivary antigens.
Afiliaciones: 
1 Unidad de Reactivos y Biomodelos de Experimentación, Facultad de Medicina, Universidad de la República, Gral. Flores 2125, Montevideo, Uruguay (mbreijo@fmed.edu.uy; gabrielrocha85@gmail.com; ximenaures@gmail.com; palonzo@higiene.edu.uy; msantos@fmed.edu.uy) mbreijo@fmed.edu.uy. 2 Laboratorio de Interacciones Moleculares, Facultad de Ciencias, Iguá 4225, 11400 Montevideo, Uruguay (lpastro@fcien.edu.uy). 3 Unidad de Reactivos y Biomodelos de Experimentación, Facultad de Medicina, Universidad de la República, Gral. Flores 2125, Montevideo, Uruguay (mbreijo@fmed.edu.uy; gabrielrocha85@gmail.com; ximenaures@gmail.com; palonzo@higiene.edu.uy; msantos@fmed.edu.uy). 4 Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República, Gral. Flores 2125, Montevideo, Uruguay (cbolatto@fmed.edu.uy). 5 Cátedra de Inmunología, Facultad de Química, Instituto de Higiene, Universidad de la República, Av. Alfredo Navarro 3051, 11600 Montevideo, Uruguay (cfernan@fq.edu.uy). 6 Laboratorio de Técnicas Nucleares, Facultad de Veterinaria, Universidad de la República, Lasplaces 1550, Montevideo, Uruguay (meikleana@gmail.com).
Enlace pubmed: 
https://pubmed.ncbi.nlm.nih.gov/27329632/
Enlace full text: 
https://academic.oup.com/jee/article-lookup/doi/10.1093/jee/tow133
Cita: 
Breijo M, Pastro L, Rocha S, Ures X, Alonzo P, Santos M, Bolatto C, Fernández C, Meikle A. A Natural Cattle Immune Response Against Horn Fly (Diptera: Muscidae) Salivary Antigens May Regulate Parasite Blood Intake. J Econ Entomol. 2016 Aug;109(4):1951-6. doi: 10.1093/jee/tow133. Epub 2016 Jun 21. PMID: 27329632.