CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype

Posted by Ernesto on Tuesday, 3 June 2025
Autores: 
Hugo Peluffo 1 2 , Patricia Solari-Saquieres 3 , Maria Luciana Negro-Demontel 4 , Isaac Francos-Quijorna 5 , Xavier Navarro 6 , Ruben López-Vales 7 , Joan Sayós 8 , Natalia Lago 9 10
Revista (o libro): 
J Neuroinflammation
Año: 
2015
Mes-dia: 
0812
issue, vol, paginas, etc: 
12:145
doi: 
10.1186/s12974-015-0364-y
PMID: 
26259611
Abstract: 
Background: It has recently become evident that activating/inhibitory cell surface immune receptors play a critical role in regulating immune and inflammatory processes in the central nervous system (CNS). The immunoreceptor CD300f expressed on monocytes, neutrophils, and mast cells modulates inflammation, phagocytosis, and outcome in models of autoimmune demyelination, allergy, and systemic lupus erythematosus. On the other hand, a finely regulated inflammatory response is essential to induce regeneration after injury to peripheral nerves since hematogenous macrophages, together with resident macrophages and de-differentiated Schwann cells, phagocyte distal axonal and myelin debris in a well-orchestrated inflammatory response. The possible roles and expression of CD300f and its ligands have not been reported under these conditions.
Afiliaciones: 
1 Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur Montevideo, Mataojo 2020, CP 11400, Montevideo, Uruguay. Hugo.peluffo@pasteur.edu.uy. 2 Department of Histology and Embryology, Faculty of Medicine, UDELAR, Montevideo, Uruguay. Hugo.peluffo@pasteur.edu.uy. 3 Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur Montevideo, Mataojo 2020, CP 11400, Montevideo, Uruguay. patricia.solari08@gmail.com. 4 Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur Montevideo, Mataojo 2020, CP 11400, Montevideo, Uruguay. luchanegro@gmail.com. 5 Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Bellaterra, Spain. isaac.francos@uab.cat. 6 Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Bellaterra, Spain. Xavier.Navarro@uab.es. 7 Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Bellaterra, Spain. ruben.lopez@uab.cat. 8 Immunobiology Group, CIBBIM-Nanomedicine Program, Hospital Universitari Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autonoma de Barcelona, Barcelona, Spain. joan.sayos@vhir.org. 9 Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur Montevideo, Mataojo 2020, CP 11400, Montevideo, Uruguay. nlago@pasteur.edu.uy. 10 Neurodegeneration Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay. nlago@pasteur.edu.uy.
Enlace pubmed: 
https://pubmed.ncbi.nlm.nih.gov/26259611/
Enlace full text: 
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-015-0364-y
Cita: 
Peluffo H, Solari-Saquieres P, Negro-Demontel ML, Francos-Quijorna I, Navarro X, López-Vales R, Sayós J, Lago N. CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype. J Neuroinflammation. 2015 Aug 12;12:145. doi: 10.1186/s12974-015-0364-y. PMID: 26259611; PMCID: PMC4531482.