CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline

Posted by Ernesto on Thursday, 29 May 2025
Autores: 
Frances Evans 1 , Daniela Alí-Ruiz 2 , Natalia Rego 3 , María Luciana Negro-Demontel 1 , Natalia Lago 2 , Fabio Andrés Cawen 2 , Bruno Pannunzio 1 , Paula Sanchez-Molina 4 , Laura Reyes 5 , Andrea Paolino 5 , Jorge Rodríguez-Duarte 6 , Valentina Pérez-Torrado 7 , Almudena Chicote-González 8 , Celia Quijano 9 , Inés Marmisolle 9 , Ana Paula Mulet 10 , Geraldine Schlapp 10 , María Noel Meikle 10 , Mariana Bresque 7 , Martina Crispo 10 , Eduardo Savio 5 , Cristina Malagelada 8 , Carlos Escande 7 , Hugo Peluffo 11
Revista (o libro): 
Cell Rep
Año: 
2023
Mes-dia: 
1031
issue, vol, paginas, etc: 
Oct 31;42(10):113269
doi: 
10.1016/j.celrep.2023.113269
PMID: 
37864797
Abstract: 
Emerging evidence suggests that immune receptors may participate in many aging-related processes such as energy metabolism, inflammation, and cognitive decline. CD300f, a TREM2-like lipid-sensing immune receptor, is an exceptional receptor as it integrates activating and inhibitory cell-signaling pathways that modulate inflammation, efferocytosis, and microglial metabolic fitness. We hypothesize that CD300f can regulate systemic aging-related processes and ultimately healthy lifespan. We closely followed several cohorts of two strains of CD300f-/- and WT mice of both sexes for 30 months and observed an important reduction in lifespan and healthspan in knockout mice. This was associated with systemic inflammaging, increased cognitive decline, reduced brain glucose uptake observed by 18FDG PET scans, enrichment in microglial aging/neurodegeneration phenotypes, proteostasis alterations, senescence, increased frailty, and sex-dependent systemic metabolic changes. Moreover, the absence of CD300f altered macrophage immunometabolic phenotype. Taken together, we provide strong evidence suggesting that myeloid cell CD300f immune receptor contributes to healthy aging.
Afiliaciones: 
1 Department of Histology and Embryology, Faculty of Medicine, UDELAR, Montevideo, Uruguay; Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay. 2 Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay. 3 Bioinformatics Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay; Faculty of Sciences, UDELAR, Montevideo, Uruguay. 4 Department of Cell Biology, Physiology and Immunology, and Institute of Neuroscience, Universitat Autònoma de Barcelona, Barcelona, Spain. 5 Uruguayan Center for Molecular Imaging (CUDIM), Montevideo, Uruguay. 6 Laboratory of Vascular Biology and Drug Development, INDICYO Program, Institut Pasteur Montevideo, Montevideo, Uruguay. 7 Metabolic Diseases and Aging Laboratory, INDICYO Program, Institut Pasteur de Montevideo, Montevideo, Uruguay. 8 Unitat de Bioquímica i Biologia Molecular, Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain; Institut de Neurociències, Universitat de Barcelona (UB), Barcelona, Spain. 9 Departamento de Bioquímica y Centro de Investigaciones Biomédicas (CEINBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. 10 Unidad de Biotecnología en Animales de Laboratorio, Institut Pasteur de Montevideo, Montevideo, Uruguay. 11 Department of Histology and Embryology, Faculty of Medicine, UDELAR, Montevideo, Uruguay; Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay; Unitat de Bioquímica i Biologia Molecular, Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain; Institut de Neurociències, Universitat de Barcelona (UB), Barcelona, Spain. Electronic address: hugo.peluffo@ub.edu.
Enlace pubmed: 
https://pubmed.ncbi.nlm.nih.gov/37864797/
Enlace full text: 
https://linkinghub.elsevier.com/retrieve/pii/S2211-1247(23)01281-0
Cita: 
Evans F, Alí-Ruiz D, Rego N, Negro-Demontel ML, Lago N, Cawen FA, Pannunzio B, Sanchez-Molina P, Reyes L, Paolino A, Rodríguez-Duarte J, Pérez-Torrado V, Chicote-González A, Quijano C, Marmisolle I, Mulet AP, Schlapp G, Meikle MN, Bresque M, Crispo M, Savio E, Malagelada C, Escande C, Peluffo H. CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline. Cell Rep. 2023 Oct 31;42(10):113269. doi: 10.1016/j.celrep.2023.113269. PMID: 37864797.